Identification of the gene loci that predispose to rheumatoid arthritis

Identification of the gene loci that predispose to rheumatoid arthritis

We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International immunology 1998-12, Vol.10 (12), p.1891-1895
Hauptverfasser: Shiozawa, S, Hayashi, S, Tsukamoto, Y, Goko, H, Kawasaki, H, Wada, T, Shimizu, K, Yasuda, N, Kamatani, N, Takasugi, K, Tanaka, Y, Shiozawa, K, Imura, S
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis, Rheumatoid - genetics
Chromosome Mapping
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Humans
Male
Microsatellite Repeats
Pedigree
Polymerase Chain Reaction
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marker loci. Markers were amplified by the PCR using fluorescence-tagged primers and sized based on the difference of CA repeats on DNA. Linkage analysis was made using maximum lod score (MLS). The MLS for D1S214 and D8S556 was 3.27 and 3.33, while the MLS for the HLA-DRB1 region was
ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/10.12.1891