Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus
Abstract Aim We examined genetic polymorphisms in the renin–angiotensin system (RAS) coding for angiotensin I-converting enzyme ( ACE ) insertion/deletion ( I/D ) for angiotensinogen ( AGT ) M235T and angiotensin II receptor type 1 ( AGTR1 ) A1166C as predictors for the development of microalbuminur...
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| Veröffentlicht in: | Journal of diabetes and its complications 2008-05, Vol.22 (3), p.191-198 |
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| creator | Gallego, Patricia H Shephard, Neil Bulsara, Max K van Bockxmeer, Frank M Powell, Brenda L Beilby, John P Arscott, Gillian Le Page, Michael Palmer, Lyle J Davis, Elizabeth A Jones, Timothy W Choong, Catherine S.Y |
| description | Abstract Aim We examined genetic polymorphisms in the renin–angiotensin system (RAS) coding for angiotensin I-converting enzyme ( ACE ) insertion/deletion ( I/D ) for angiotensinogen ( AGT ) M235T and angiotensin II receptor type 1 ( AGTR1 ) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9–18.3); diabetes duration, 6.9 years (3.3–10.8); age at diagnosis, 9.1 years (5.8–11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of ≥20 and |
| doi_str_mv | 10.1016/j.jdiacomp.2007.03.003 |
| format | Article |
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Methods Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9–18.3); diabetes duration, 6.9 years (3.3–10.8); age at diagnosis, 9.1 years (5.8–11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of ≥20 and <200 μg/min). Kaplan–Meier survival curves and Cox proportional multivariate model estimated the probability of developing MA and the relative risk for MA among different variables. Results MA developed in 41 (9.1%) subjects. The frequencies of genotypes were as follows: ACE-II 112 (25%), ACE-ID 221 (49%), and ACE-DD 117 (26%) ( n =450); AGT-MM 144 (32%), AGT-MT 231 (51%), and AGT-TT 77 (17%) ( n =452); AGTR1-AA 211 (47%), AGTR1-AC 204 (45%), and AGTR1-CC 37 (8%) ( n =452). The cumulative risk for the development of MA was higher in ACE-DD versus ACE-ID/II groups (log-rank test, P =.05), and a trend was noticed when AGT-TT was compared to AGT-MT/MM groups (log-rank test, P =.08). AGT-TT polymorphism conferred a fourfold increased risk for MA compared to AGT-MM/MT (hazard ratio=3.8; 95% confidence interval=1.43–10.3; P =.008). Interpretation Our findings suggest that RAS gene polymorphism at AGT M235T is a strong predictor for early MA in young T1DM subjects.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2007.03.003</identifier><identifier>PMID: 18413222</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Albumin excretion rate ; Albuminuria - genetics ; Angiotensinogen - genetics ; Australia ; Cardiovascular disease ; Child ; Diabetes ; Diabetes Mellitus, Type 1 - urine ; Diabetic Nephropathies - genetics ; DNA Primers ; Endocrinology & Metabolism ; European Continental Ancestry Group ; Female ; Genetic Markers ; Genetic Variation ; Genotype ; Humans ; Hypertension ; Kidneys ; Male ; Microalbuminuria ; Nephropathy ; Polymorphism, Single Nucleotide ; Renin-Angiotensin System - physiology ; Renin–angiotensin system ; Reverse Transcriptase Polymerase Chain Reaction ; Type 1 diabetes mellitus</subject><ispartof>Journal of diabetes and its complications, 2008-05, Vol.22 (3), p.191-198</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-6031a73f8cbe6e1770c4ce7de17558733ed4f7e34a1d91515bd4d1b161d5ee0c3</citedby><cites>FETCH-LOGICAL-c449t-6031a73f8cbe6e1770c4ce7de17558733ed4f7e34a1d91515bd4d1b161d5ee0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033362629?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18413222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallego, Patricia H</creatorcontrib><creatorcontrib>Shephard, Neil</creatorcontrib><creatorcontrib>Bulsara, Max K</creatorcontrib><creatorcontrib>van Bockxmeer, Frank M</creatorcontrib><creatorcontrib>Powell, Brenda L</creatorcontrib><creatorcontrib>Beilby, John P</creatorcontrib><creatorcontrib>Arscott, Gillian</creatorcontrib><creatorcontrib>Le Page, Michael</creatorcontrib><creatorcontrib>Palmer, Lyle J</creatorcontrib><creatorcontrib>Davis, Elizabeth A</creatorcontrib><creatorcontrib>Jones, Timothy W</creatorcontrib><creatorcontrib>Choong, Catherine S.Y</creatorcontrib><title>Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Abstract Aim We examined genetic polymorphisms in the renin–angiotensin system (RAS) coding for angiotensin I-converting enzyme ( ACE ) insertion/deletion ( I/D ) for angiotensinogen ( AGT ) M235T and angiotensin II receptor type 1 ( AGTR1 ) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9–18.3); diabetes duration, 6.9 years (3.3–10.8); age at diagnosis, 9.1 years (5.8–11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of ≥20 and <200 μg/min). Kaplan–Meier survival curves and Cox proportional multivariate model estimated the probability of developing MA and the relative risk for MA among different variables. Results MA developed in 41 (9.1%) subjects. The frequencies of genotypes were as follows: ACE-II 112 (25%), ACE-ID 221 (49%), and ACE-DD 117 (26%) ( n =450); AGT-MM 144 (32%), AGT-MT 231 (51%), and AGT-TT 77 (17%) ( n =452); AGTR1-AA 211 (47%), AGTR1-AC 204 (45%), and AGTR1-CC 37 (8%) ( n =452). The cumulative risk for the development of MA was higher in ACE-DD versus ACE-ID/II groups (log-rank test, P =.05), and a trend was noticed when AGT-TT was compared to AGT-MT/MM groups (log-rank test, P =.08). AGT-TT polymorphism conferred a fourfold increased risk for MA compared to AGT-MM/MT (hazard ratio=3.8; 95% confidence interval=1.43–10.3; P =.008). Interpretation Our findings suggest that RAS gene polymorphism at AGT M235T is a strong predictor for early MA in young T1DM subjects.</description><subject>Adolescent</subject><subject>Albumin excretion rate</subject><subject>Albuminuria - genetics</subject><subject>Angiotensinogen - genetics</subject><subject>Australia</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - urine</subject><subject>Diabetic Nephropathies - genetics</subject><subject>DNA Primers</subject><subject>Endocrinology & Metabolism</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidneys</subject><subject>Male</subject><subject>Microalbuminuria</subject><subject>Nephropathy</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Renin–angiotensin system</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Type 1 diabetes mellitus</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl2L1TAQhoso7rr6F5aA4F1rPtq09UJcFr9gwQtX8C6kyXRPumlSk_TI-Sf-XFPOkYW98SJkAs9MZt53iuKS4Ipgwt9O1aSNVH5eKopxW2FWYcyeFOeka1lZc_zzaY5xw8uupe1Z8SLGCWPMm4Y8L85IVxNGKT0v_ly5O-MTuGicvwOH8gF0S1mD9jIY6dI7JNEswz0ENPqA0g6Qhj1Yv8zgEvIjWiBEE9P2mo0KXtphnY1bczoyDqmdsTrk0tJpJLW3EFVmI_pt0g6lwwKIoDzMAAkimsFak9b4sng2Shvh1em-KH58-nh7_aW8-fb56_XVTanquk8lx4zIlo2dGoADaVusagWtzmHTZCkY6HpsgdWS6J40pBl0rclAONENAFbsonhzrLsE_2uFmMRscn_WSgd-jYL3hPZdjTP4-hE4-TW43JsgmDHGKad9pviRyjrEGGAUSzBZvkOGxOacmMQ_58TmnMBMZOdy4uWp_DrMoB_STlZl4MMRgKzG3kAQURlwCrQJoJLQ3vz_j_ePSihrnFHS3sMB4sM8IlKBxfdtf7b1wW1eHUYI-wtG_cSL</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Gallego, Patricia H</creator><creator>Shephard, Neil</creator><creator>Bulsara, Max K</creator><creator>van Bockxmeer, Frank M</creator><creator>Powell, Brenda L</creator><creator>Beilby, John P</creator><creator>Arscott, Gillian</creator><creator>Le Page, Michael</creator><creator>Palmer, Lyle J</creator><creator>Davis, Elizabeth A</creator><creator>Jones, Timothy W</creator><creator>Choong, Catherine S.Y</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus</title><author>Gallego, Patricia H ; Shephard, Neil ; Bulsara, Max K ; van Bockxmeer, Frank M ; Powell, Brenda L ; Beilby, John P ; Arscott, Gillian ; Le Page, Michael ; Palmer, Lyle J ; Davis, Elizabeth A ; Jones, Timothy W ; Choong, Catherine S.Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-6031a73f8cbe6e1770c4ce7de17558733ed4f7e34a1d91515bd4d1b161d5ee0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Albumin excretion rate</topic><topic>Albuminuria - genetics</topic><topic>Angiotensinogen - genetics</topic><topic>Australia</topic><topic>Cardiovascular disease</topic><topic>Child</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - urine</topic><topic>Diabetic Nephropathies - genetics</topic><topic>DNA Primers</topic><topic>Endocrinology & Metabolism</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidneys</topic><topic>Male</topic><topic>Microalbuminuria</topic><topic>Nephropathy</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Renin–angiotensin system</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Type 1 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallego, Patricia H</creatorcontrib><creatorcontrib>Shephard, Neil</creatorcontrib><creatorcontrib>Bulsara, Max K</creatorcontrib><creatorcontrib>van Bockxmeer, Frank M</creatorcontrib><creatorcontrib>Powell, Brenda L</creatorcontrib><creatorcontrib>Beilby, John P</creatorcontrib><creatorcontrib>Arscott, Gillian</creatorcontrib><creatorcontrib>Le Page, Michael</creatorcontrib><creatorcontrib>Palmer, Lyle J</creatorcontrib><creatorcontrib>Davis, Elizabeth A</creatorcontrib><creatorcontrib>Jones, Timothy W</creatorcontrib><creatorcontrib>Choong, Catherine S.Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallego, Patricia H</au><au>Shephard, Neil</au><au>Bulsara, Max K</au><au>van Bockxmeer, Frank M</au><au>Powell, Brenda L</au><au>Beilby, John P</au><au>Arscott, Gillian</au><au>Le Page, Michael</au><au>Palmer, Lyle J</au><au>Davis, Elizabeth A</au><au>Jones, Timothy W</au><au>Choong, Catherine S.Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>22</volume><issue>3</issue><spage>191</spage><epage>198</epage><pages>191-198</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Abstract Aim We examined genetic polymorphisms in the renin–angiotensin system (RAS) coding for angiotensin I-converting enzyme ( ACE ) insertion/deletion ( I/D ) for angiotensinogen ( AGT ) M235T and angiotensin II receptor type 1 ( AGTR1 ) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM). Methods Four hundred fifty-three (215 males, 238 females) T1DM children [median (interquartile range): age, 16.7 years (13.9–18.3); diabetes duration, 6.9 years (3.3–10.8); age at diagnosis, 9.1 years (5.8–11.8)] were followed prospectively from diagnosis until the development of MA (two of three consecutive overnight urine samples with albumin excretion rates of ≥20 and <200 μg/min). Kaplan–Meier survival curves and Cox proportional multivariate model estimated the probability of developing MA and the relative risk for MA among different variables. Results MA developed in 41 (9.1%) subjects. The frequencies of genotypes were as follows: ACE-II 112 (25%), ACE-ID 221 (49%), and ACE-DD 117 (26%) ( n =450); AGT-MM 144 (32%), AGT-MT 231 (51%), and AGT-TT 77 (17%) ( n =452); AGTR1-AA 211 (47%), AGTR1-AC 204 (45%), and AGTR1-CC 37 (8%) ( n =452). The cumulative risk for the development of MA was higher in ACE-DD versus ACE-ID/II groups (log-rank test, P =.05), and a trend was noticed when AGT-TT was compared to AGT-MT/MM groups (log-rank test, P =.08). AGT-TT polymorphism conferred a fourfold increased risk for MA compared to AGT-MM/MT (hazard ratio=3.8; 95% confidence interval=1.43–10.3; P =.008). Interpretation Our findings suggest that RAS gene polymorphism at AGT M235T is a strong predictor for early MA in young T1DM subjects.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18413222</pmid><doi>10.1016/j.jdiacomp.2007.03.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of diabetes and its complications, 2008-05, Vol.22 (3), p.191-198 |
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| subjects | Adolescent Albumin excretion rate Albuminuria - genetics Angiotensinogen - genetics Australia Cardiovascular disease Child Diabetes Diabetes Mellitus, Type 1 - urine Diabetic Nephropathies - genetics DNA Primers Endocrinology & Metabolism European Continental Ancestry Group Female Genetic Markers Genetic Variation Genotype Humans Hypertension Kidneys Male Microalbuminuria Nephropathy Polymorphism, Single Nucleotide Renin-Angiotensin System - physiology Renin–angiotensin system Reverse Transcriptase Polymerase Chain Reaction Type 1 diabetes mellitus |
| title | Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus |
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