High level serum neutralizing antibody against HIV-1 in Chinese long-term non-progressors

ABSTRACT NAb have been considered to be an important component of a protective immune response to HIV‐1, yet the relationship between the capacity of HIV‐1 NAb, the conserved neutralization epitopes and disease progression has been unclear. To gain a better understanding of the protective roles that NAb and conserved neutralization epitopes could play in LTNP, twenty‐eight HIV‐1‐infected subjects were investigated by evaluation of the concentrations of HIV‐1 NAb and conserved neutralization epitopes, using single‐round PBMC neutralization assay and sequencing. Our study revealed that the concentration of NAb in LTNP was significantly higher than that in subjects with asymptomatic HIV (P