Monoclonal Antibody-Resistant Mutants Selected with a Respiratory Syncytial Virus-Neutralizing Human Antibody Fab Fragment (Fab 19) Define a Unique Epitope on the Fusion (F) Glycoprotein

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizin...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1998-12, Vol.252 (2), p.373-375
Hauptverfasser:	Crowe, James E., Firestone, Cai-Yen, Crim, Roberta, Beeler, Judy A., Coelingh, Kathleen L., Barbas, Carlos F., Burton, Dennis R., Chanock, Robert M., Murphy, Brian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Antibodies, Monoclonal Cell Line Epitopes - analysis Humans Immunoglobulin Fab Fragments Neutralization Tests Point Mutation Recombinant Proteins respiratory syncytial virus Respiratory Syncytial Viruses - genetics Respiratory Syncytial Viruses - immunology Tumor Cells, Cultured Viral Fusion Proteins - analysis Viral Fusion Proteins - genetics Viral Fusion Proteins - immunology
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Beschreibung
Zusammenfassung:	A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.
ISSN:	0042-6822 1096-0341
DOI:	10.1006/viro.1998.9462