Tetramic and tetronic acids: An update on new derivatives and biological aspects

Progress in the field of tetramic acids and tetronic acids since the year 2000 is reviewed with a focus on newly isolated derivatives, on biosynthetic pathways, biological and pharmacological activities and on recent laboratory syntheses. Significant developments in the isolation of tetramic acids and tetronic acids, in the elucidation of their biosyntheses and their biological activities and in laboratory syntheses are reviewed with a focus on those derivatives with medicinal and pharmacological relevance. Important new members of the title compound families isolated since the year 2000 are covered as well as new biological aspects of some earlier congeners.