Antioxidant Vitamins and Coronary Artery Disease Risk in South African Males
Decreased antioxidant–vitamin nutritional status may increase lipid peroxidation and susceptibility of low-density lipoprotein (LDL) to oxidative modification. The aim of this study was to evaluate the vitamin nutritional status of coronary artery disease (CAD) patients and to assess the risk of CAD...
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| Veröffentlicht in: | Clinica chimica acta 1998-11, Vol.278 (1), p.55-60 |
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| container_title | Clinica chimica acta |
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| creator | Delport, Rhena B Ubbink, Johan A. Human, Johanna J Becker, Piet P Myburgh, Dirk Hayward Vermaak, WJ |
| description | Decreased antioxidant–vitamin nutritional status may increase lipid peroxidation and susceptibility of low-density lipoprotein (LDL) to oxidative modification. The aim of this study was to evaluate the vitamin nutritional status of coronary artery disease (CAD) patients and to assess the risk of CAD related to each individual antioxidant vitamin. The study was performed as a case-control study with 41 patients with angiographically demonstrated CAD and 41 apparently healthy age- and smoking status-matched controls. Plasma vitamin E, C and A concentrations were significantly decreased in CAD patients compared with controls (p |
| doi_str_mv | 10.1016/S0009-8981(98)00131-4 |
| format | Article |
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Human, Johanna ; J Becker, Piet ; P Myburgh, Dirk ; Hayward Vermaak, WJ</creator><creatorcontrib>Delport, Rhena ; B Ubbink, Johan ; A. Human, Johanna ; J Becker, Piet ; P Myburgh, Dirk ; Hayward Vermaak, WJ</creatorcontrib><description>Decreased antioxidant–vitamin nutritional status may increase lipid peroxidation and susceptibility of low-density lipoprotein (LDL) to oxidative modification. The aim of this study was to evaluate the vitamin nutritional status of coronary artery disease (CAD) patients and to assess the risk of CAD related to each individual antioxidant vitamin. The study was performed as a case-control study with 41 patients with angiographically demonstrated CAD and 41 apparently healthy age- and smoking status-matched controls. Plasma vitamin E, C and A concentrations were significantly decreased in CAD patients compared with controls (p<0.001) after correcting for significant covariates. Per quartile decrease in vitamin A and E concentrations was associated with increased risk of CAD, even after adjusting for CAD risk factors, while per quartile decrease in vitamin C concentrations was not associated with significant CAD risk after adjusting for CAD risk factors. Decreased vitamin A and E concentrations are independently associated with increased risk of CAD independent from other CAD risk factors in white male South Africans and dietary intervention strategies are advocated.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/S0009-8981(98)00131-4</identifier><identifier>PMID: 9877124</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Antioxidants - therapeutic use ; Biological and medical sciences ; CAD risk ; Cardiology. Vascular system ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary Disease - epidemiology ; Coronary Disease - metabolism ; Coronary Disease - prevention & control ; Coronary heart disease ; Heart ; Humans ; Lipid Peroxidation ; Male ; Medical sciences ; Middle Aged ; Smoking ; South Africa - epidemiology ; Vitamin A ; Vitamin C ; Vitamin E ; Vitamins - therapeutic use</subject><ispartof>Clinica chimica acta, 1998-11, Vol.278 (1), p.55-60</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-449bd6ba81b85e51abddc4a13f07cf3954627dbdc9c8b15336eff264329bd3e03</citedby><cites>FETCH-LOGICAL-c389t-449bd6ba81b85e51abddc4a13f07cf3954627dbdc9c8b15336eff264329bd3e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0009-8981(98)00131-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1660238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9877124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delport, Rhena</creatorcontrib><creatorcontrib>B Ubbink, Johan</creatorcontrib><creatorcontrib>A. Human, Johanna</creatorcontrib><creatorcontrib>J Becker, Piet</creatorcontrib><creatorcontrib>P Myburgh, Dirk</creatorcontrib><creatorcontrib>Hayward Vermaak, WJ</creatorcontrib><title>Antioxidant Vitamins and Coronary Artery Disease Risk in South African Males</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Decreased antioxidant–vitamin nutritional status may increase lipid peroxidation and susceptibility of low-density lipoprotein (LDL) to oxidative modification. The aim of this study was to evaluate the vitamin nutritional status of coronary artery disease (CAD) patients and to assess the risk of CAD related to each individual antioxidant vitamin. The study was performed as a case-control study with 41 patients with angiographically demonstrated CAD and 41 apparently healthy age- and smoking status-matched controls. Plasma vitamin E, C and A concentrations were significantly decreased in CAD patients compared with controls (p<0.001) after correcting for significant covariates. Per quartile decrease in vitamin A and E concentrations was associated with increased risk of CAD, even after adjusting for CAD risk factors, while per quartile decrease in vitamin C concentrations was not associated with significant CAD risk after adjusting for CAD risk factors. Decreased vitamin A and E concentrations are independently associated with increased risk of CAD independent from other CAD risk factors in white male South Africans and dietary intervention strategies are advocated.</description><subject>Adult</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>CAD risk</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary heart disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Smoking</subject><subject>South Africa - epidemiology</subject><subject>Vitamin A</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamins - therapeutic use</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BCEHET1UkyZNk5Ms6yesCH5dQ5pMMdpNNemK_nuju-jR0zDM884kD0K7lBxRQsXxHSFEFVJJeqDkISGU0YKvoBGVNSsYV-UqGv0iG2gzpefcciLoOlpXsq5pyUdoOg6D7z-8M2HAj34wMx8SNsHhSR_7YOInHscBcjn1CUwCfOvTC_YB3_Xz4QmP2-itCfjadJC20VprugQ7y7qFHs7P7ieXxfTm4moynhaWSTUUnKvGicZI2sgKKmoa5yw3lLWkti1TFRdl7RpnlZUNrRgT0Lal4KzMOQaEbaH9xd7X2L_NIQ165pOFrjMB-nnSQtGSlqrOYLUAbexTitDq1-hn-VOaEv1tUf9Y1N-KtJL6x6LmObe7PDBvZuB-U0tteb63nJtkTddGE6xPf8uFICWTGTtZYJBlvHuIOlkPwYLzEeygXe__ecgXHqaOFQ</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Delport, Rhena</creator><creator>B Ubbink, Johan</creator><creator>A. Human, Johanna</creator><creator>J Becker, Piet</creator><creator>P Myburgh, Dirk</creator><creator>Hayward Vermaak, WJ</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Antioxidant Vitamins and Coronary Artery Disease Risk in South African Males</title><author>Delport, Rhena ; B Ubbink, Johan ; A. Human, Johanna ; J Becker, Piet ; P Myburgh, Dirk ; Hayward Vermaak, WJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-449bd6ba81b85e51abddc4a13f07cf3954627dbdc9c8b15336eff264329bd3e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>CAD risk</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary Disease - prevention & control</topic><topic>Coronary heart disease</topic><topic>Heart</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Smoking</topic><topic>South Africa - epidemiology</topic><topic>Vitamin A</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delport, Rhena</creatorcontrib><creatorcontrib>B Ubbink, Johan</creatorcontrib><creatorcontrib>A. Human, Johanna</creatorcontrib><creatorcontrib>J Becker, Piet</creatorcontrib><creatorcontrib>P Myburgh, Dirk</creatorcontrib><creatorcontrib>Hayward Vermaak, WJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delport, Rhena</au><au>B Ubbink, Johan</au><au>A. Human, Johanna</au><au>J Becker, Piet</au><au>P Myburgh, Dirk</au><au>Hayward Vermaak, WJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Vitamins and Coronary Artery Disease Risk in South African Males</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>278</volume><issue>1</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>Decreased antioxidant–vitamin nutritional status may increase lipid peroxidation and susceptibility of low-density lipoprotein (LDL) to oxidative modification. The aim of this study was to evaluate the vitamin nutritional status of coronary artery disease (CAD) patients and to assess the risk of CAD related to each individual antioxidant vitamin. The study was performed as a case-control study with 41 patients with angiographically demonstrated CAD and 41 apparently healthy age- and smoking status-matched controls. Plasma vitamin E, C and A concentrations were significantly decreased in CAD patients compared with controls (p<0.001) after correcting for significant covariates. Per quartile decrease in vitamin A and E concentrations was associated with increased risk of CAD, even after adjusting for CAD risk factors, while per quartile decrease in vitamin C concentrations was not associated with significant CAD risk after adjusting for CAD risk factors. Decreased vitamin A and E concentrations are independently associated with increased risk of CAD independent from other CAD risk factors in white male South Africans and dietary intervention strategies are advocated.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>9877124</pmid><doi>10.1016/S0009-8981(98)00131-4</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Antioxidants - therapeutic use Biological and medical sciences CAD risk Cardiology. Vascular system Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Disease - epidemiology Coronary Disease - metabolism Coronary Disease - prevention & control Coronary heart disease Heart Humans Lipid Peroxidation Male Medical sciences Middle Aged Smoking South Africa - epidemiology Vitamin A Vitamin C Vitamin E Vitamins - therapeutic use |
| title | Antioxidant Vitamins and Coronary Artery Disease Risk in South African Males |
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