Biologically selective potassium channel openers having 1,1-diethylpropyl group

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity....

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (23), p.3397-3402
Hauptverfasser:	Yoshiizumi, Kazuya, Seko, Norihiko, Nishimura, Noriyasu, Ikeda, Shoji, Yoshino, Kohichiro, Kondo, Hirosato, Tanizawa, Kazutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Antihypertensive Agents - chemical synthesis Antihypertensive Agents - pharmacology Biological and medical sciences Cardiovascular system Cromakalim - pharmacology Dogs Intestines - drug effects Medical sciences Pharmacology. Drug treatments Pinacidil - pharmacology Potassium Channels - drug effects Structure-Activity Relationship Trachea - drug effects Trachea - physiology Urinary Bladder - drug effects Urinary Bladder - physiology
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Beschreibung
Zusammenfassung:	To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity. Selective potassium channel openers with 1,1-diethylpropyl group toward antihypertensive activity are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00625-8