Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative ( 19) showed strong antimitotic activity and cytotoxi...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (23), p.3371-3374 |
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| container_issue | 23 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | Hatanaka, Toshihiro Fujita, Koichi Ohsumi, Koji Nakagawa, Ryusuke Fukuda, Yumiko Nihei, Yukio Suga, Yasuyo Akiyama, Yukio Tsuji, Takashi |
| description | A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (
19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.
The syntheses and antineoplastic activity of B-ring modified combretastatin analogues are discussed. |
| doi_str_mv | 10.1016/S0960-894X(98)00622-2 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3371-3374 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69119423 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Bibenzyls - chemical synthesis Bibenzyls - pharmacology Biological and medical sciences Drug Stability General aspects Humans Medical sciences Pharmacology. Drug treatments Stilbenes Structure-Activity Relationship |
| title | Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity |
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