Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity

A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative ( 19) showed strong antimitotic activity and cytotoxi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (23), p.3371-3374
Hauptverfasser:	Hatanaka, Toshihiro, Fujita, Koichi, Ohsumi, Koji, Nakagawa, Ryusuke, Fukuda, Yumiko, Nihei, Yukio, Suga, Yasuyo, Akiyama, Yukio, Tsuji, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Bibenzyls - chemical synthesis Bibenzyls - pharmacology Biological and medical sciences Drug Stability General aspects Humans Medical sciences Pharmacology. Drug treatments Stilbenes Structure-Activity Relationship
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Zusammenfassung:	A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative ( 19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility. The syntheses and antineoplastic activity of B-ring modified combretastatin analogues are discussed.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00622-2