Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors. Graphic

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (23), p.3353-3358
Hauptverfasser: Wischnat, Ralf, Martin, Richard, Takayama, Shuichi, Wong, Chi-Huey
Format: Artikel
Sprache:eng
Schlagworte:
alpha-L-Fucosidase - antagonists & inhibitors
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Enzyme Inhibitors - chemical synthesis
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00617-9