An alternative synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an intermediate in sterol biosynthesis and a reported activator of meiosis and of nuclear orphan receptor LXRα

4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, a sterol of current biological interest, has been synthesized in six steps from 3β-acetoxy-4,4-dimethyl-5α-cholest-8(14)-en-15-one. 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol ( I), a sterol of current biological interest, has been synthesized in six st...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-02, Vol.8 (3), p.233-236
Hauptverfasser:	Ruan, B, Wilson, W.K, Schroepfer, G.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Cholestenes - chemical synthesis Cholestenes - chemistry Cholestenes - pharmacology DNA-Binding Proteins Exact sciences and technology Liver X Receptors Meiosis - drug effects Organic chemistry Orphan Nuclear Receptors Preparations and properties Receptors, Cytoplasmic and Nuclear - metabolism Steroids Sterols - biosynthesis
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Zusammenfassung:	4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, a sterol of current biological interest, has been synthesized in six steps from 3β-acetoxy-4,4-dimethyl-5α-cholest-8(14)-en-15-one. 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol ( I), a sterol of current biological interest, has been synthesized in six steps from 3β-acetoxy-4,4-dimethyl-5α-cholest-8(14)-en-15-one ( II).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00016-X