Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii
Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha...
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| Veröffentlicht in: | Archives of pharmacal research 1998-02, Vol.21 (1), p.67-69 |
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| container_title | Archives of pharmacal research |
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| creator | Chae, S H Kim, P S Cho, J Y Park, J S Lee, J H Yoo, E S Baik, K U Lee, J S Park, M H |
| description | Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM). |
| doi_str_mv | 10.1007/BF03216755 |
| format | Article |
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They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. 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| ispartof | Archives of pharmacal research, 1998-02, Vol.21 (1), p.67-69 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Cell Line Chromatography, High Pressure Liquid Chromatography, Thin Layer Humans Macrophages - drug effects Macrophages - metabolism Plant Extracts - pharmacology Plants, Medicinal - chemistry Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis |
| title | Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii |
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