Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii

Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha...

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Veröffentlicht in:	Archives of pharmacal research 1998-02, Vol.21 (1), p.67-69
Hauptverfasser:	Chae, S H, Kim, P S, Cho, J Y, Park, J S, Lee, J H, Yoo, E S, Baik, K U, Lee, J S, Park, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Chromatography, High Pressure Liquid Chromatography, Thin Layer Humans Macrophages - drug effects Macrophages - metabolism Plant Extracts - pharmacology Plants, Medicinal - chemistry Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis
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Beschreibung
Zusammenfassung:	Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).
ISSN:	0253-6269
DOI:	10.1007/BF03216755