Development of new chromanol antagonists of leukotriene D4

By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-07, Vol.8 (14), p.1791-1796
Hauptverfasser:	CHAMBERS, R. J, ANTOGNOLI, G. W, CHENG, J. B, MARFAT, A, PILLAR, J. S, SHIRLEY, J. T, WATSON, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromans - chemistry Chromans - metabolism Chromans - pharmacology Chromones - pharmacology Guinea Pigs Humans Leukotriene Antagonists - chemistry Leukotriene Antagonists - metabolism Leukotriene Antagonists - pharmacology Leukotriene D4 - antagonists & inhibitors Leukotriene D4 - metabolism Medical sciences Pharmacology. Drug treatments Protein Binding Respiratory system Tosyl Compounds - pharmacology
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Beschreibung
Zusammenfassung:	By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/s0960-894x(98)00273-x