Alkylation of succinates: Synthesis of Ro 32–3555

A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32–3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives. A...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-01, Vol.8 (2), p.143-146
Hauptverfasser:	McClure, Kim F., Axt, Matthew Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Alkylation Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry Exact sciences and technology Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Matrix Metalloproteinase Inhibitors Medical sciences Organic chemistry Pharmacology. Drug treatments Preparations and properties Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Succinates - chemistry
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Zusammenfassung:	A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32–3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives. A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32–3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(97)10179-2