Novel quinolone derivatives as potent antibacterials

Several 7-(3 R,4 R-N,N′-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3 R,4 R-N,N′-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity aga...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-03, Vol.8 (5), p.525-528
Hauptverfasser:	Lohray, Braj B., Baskaran, S., Rao, Bonthu Srinivasa, Mallesham, B., Bharath, K.S.N., Yadi Reddy, B., Venkateswarlu, S., Sadhukhan, Ashok K., Sitaram Kumar, M., Sarnaik, Hemant M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Quinolones - chemistry Quinolones - pharmacology Species Specificity Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several 7-(3 R,4 R-N,N′-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3 R,4 R-N,N′-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram + ve organïsms. Several 7-(3 R,4 R-N,N′-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3 R,4 R-N,N′-dimethyl diamino-1-pyrrolidinyl)-6,8- difluoro-1,4 -dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have the best antibacterial activity against gram + ve organisms among the quinolone we have studied.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00063-8