Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype

Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype

Sickle cell disease (SCD) is characterised by abnormal coagulopathy and angiogenesis although their relationships in two common genotypes, homozygous (HbSS) SCD and sickle-haemoglobin C disease (HbSC), are unexplored. We measured markers of platelet activation (soluble P-selectin [sP-selectin]), fib...

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Veröffentlicht in:Journal of thrombosis and thrombolysis 2008-04, Vol.25 (2), p.185-189
Hauptverfasser: Blann, A. D., Mohan, J. S., Bareford, D., Lip, G. Y. H.
Format: Artikel
Sprache:eng
Schlagworte:
Blood Coagulation - physiology
Cardiology
Case-Control Studies
Cross-Sectional Studies
Female
Fibrin Fibrinogen Degradation Products - metabolism
Genotype
Hematology
Hemoglobin SC Disease - blood
Hemoglobin SC Disease - genetics
Hemoglobin, Sickle - genetics
Humans
Male
Medicine
Medicine & Public Health
Neovascularization, Physiologic - physiology
P-Selectin - blood
Platelet Activation - physiology
Platelet Count
Vascular Endothelial Growth Factor A - blood
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Zusammenfassung:Sickle cell disease (SCD) is characterised by abnormal coagulopathy and angiogenesis although their relationships in two common genotypes, homozygous (HbSS) SCD and sickle-haemoglobin C disease (HbSC), are unexplored. We measured markers of platelet activation (soluble P-selectin [sP-selectin]), fibrinolysis (D-dimer) and angiogenesis (vascular endothelial growth factor [VEGF]) in 27 HbSS patients, 37 HbSC patients and in 42 age and race matched subjects with normal haemoglobin (AA). sP-selectin ( P  = 0.025) and D-dimers ( P  
ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-007-0177-7