Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-07, Vol.8 (13), p.1745-1750 |
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| container_issue | 13 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | Batt, Douglas G. Petraitis, Joseph J. Sherk, Susan R. Copeland, Robert A. Dowling, Randine L. Taylor, Tracy L. Jones, Elizabeth A. Magolda, Ronald L. Jaffee, Bruce D. |
| description | Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent. |
| doi_str_mv | 10.1016/S0960-894X(98)00308-4 |
| format | Article |
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Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(98)00308-4</identifier><identifier>PMID: 9873427</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Biphenyl Compounds - chemistry ; Carbon - chemistry ; Immunomodulators ; Immunosuppressive Agents - chemistry ; Immunosuppressive Agents - pharmacology ; Lymphocyte Culture Test, Mixed ; Medical sciences ; Pharmacology. Drug treatments ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (13), p.1745-1750</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f3d8dcd9b4b895668957a0055e24ff36d7cc21f5db109f36247b6b404c0ca6023</citedby><cites>FETCH-LOGICAL-c389t-f3d8dcd9b4b895668957a0055e24ff36d7cc21f5db109f36247b6b404c0ca6023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X98003084$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2330845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9873427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batt, Douglas G.</creatorcontrib><creatorcontrib>Petraitis, Joseph J.</creatorcontrib><creatorcontrib>Sherk, Susan R.</creatorcontrib><creatorcontrib>Copeland, Robert A.</creatorcontrib><creatorcontrib>Dowling, Randine L.</creatorcontrib><creatorcontrib>Taylor, Tracy L.</creatorcontrib><creatorcontrib>Jones, Elizabeth A.</creatorcontrib><creatorcontrib>Magolda, Ronald L.</creatorcontrib><creatorcontrib>Jaffee, Bruce D.</creatorcontrib><title>Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.</description><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds - chemistry</subject><subject>Carbon - chemistry</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - chemistry</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batt, Douglas G.</creatorcontrib><creatorcontrib>Petraitis, Joseph J.</creatorcontrib><creatorcontrib>Sherk, Susan R.</creatorcontrib><creatorcontrib>Copeland, Robert A.</creatorcontrib><creatorcontrib>Dowling, Randine L.</creatorcontrib><creatorcontrib>Taylor, Tracy L.</creatorcontrib><creatorcontrib>Jones, Elizabeth A.</creatorcontrib><creatorcontrib>Magolda, Ronald L.</creatorcontrib><creatorcontrib>Jaffee, Bruce D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batt, Douglas G.</au><au>Petraitis, Joseph J.</au><au>Sherk, Susan R.</au><au>Copeland, Robert A.</au><au>Dowling, Randine L.</au><au>Taylor, Tracy L.</au><au>Jones, Elizabeth A.</au><au>Magolda, Ronald L.</au><au>Jaffee, Bruce D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>1998-07-07</date><risdate>1998</risdate><volume>8</volume><issue>13</issue><spage>1745</spage><epage>1750</epage><pages>1745-1750</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873427</pmid><doi>10.1016/S0960-894X(98)00308-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (13), p.1745-1750 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69114511 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biphenyl Compounds - chemistry Carbon - chemistry Immunomodulators Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Lymphocyte Culture Test, Mixed Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship |
| title | Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents |
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