Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-07, Vol.8 (13), p.1745-1750
Hauptverfasser:	Batt, Douglas G., Petraitis, Joseph J., Sherk, Susan R., Copeland, Robert A., Dowling, Randine L., Taylor, Tracy L., Jones, Elizabeth A., Magolda, Ronald L., Jaffee, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biphenyl Compounds - chemistry Carbon - chemistry Immunomodulators Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Lymphocyte Culture Test, Mixed Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent. Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00308-4