The development of novel and selective p56lck tyrosine kinase inhibitors

Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56lck, is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Ind...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-09, Vol.8 (18), p.2489-2494
Hauptverfasser:	BULLINGTON, J. L, CAMERON, J. C, DAVIS, J. E, DODD, J. H, HARRIS, C. A, HENRY, J. R, PELLEGRINO-GENSEY, J. L, RUPERT, K. C, SIEKIERKA, J. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Enzyme Activation Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Immunomodulators Indans - chemistry Indans - pharmacology Killer Cells, Natural - enzymology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors Medical sciences Models, Chemical Pharmacology. Drug treatments Protein-Tyrosine Kinases - antagonists & inhibitors Signal Transduction src-Family Kinases T-Lymphocytes - enzymology
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Beschreibung
Zusammenfassung:	Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56lck, is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56lck.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00445-4