Synthesis of diacylamines and the preparation of α-amino-acylureas, a new type of α-amino acid derivatives

Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters. 16 new and 2 known open-chain diacylamines...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-11, Vol.8 (22), p.3241-3244
Hauptverfasser:	Weisz, Imre, Roboz, John, Wolf, Imre, Szabo, Jozsef, Bekesi, J.George
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Amines - chemical synthesis Amino Acids - chemical synthesis Anticonvulsants - pharmacology Antineoplastic Agents - pharmacology Chemistry Exact sciences and technology Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters. 16 new and 2 known open-chain diacylamines were synthesized by Na-methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00593-9