Reversible Bone Marrow Dysplasia in Patients with Systemic Lupus Erythematosus
Objective Several reports of bone marrow dysplasia in patients with systemic lupus erythematosus (SLE) have been published. However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias...
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| Veröffentlicht in: | Internal Medicine 2008, Vol.47(8), pp.737-742 |
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| creator | Oka, Yumiko Kameoka, Junichi Hirabayashi, Yasuhiko Takahashi, Reiko Ishii, Tomonori Sasaki, Takeshi Harigae, Hideo |
| description | Objective Several reports of bone marrow dysplasia in patients with systemic lupus erythematosus (SLE) have been published. However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias is unknown. Therefore, in the present study, the dysplasias noted in bone marrow aspirates obtained from SLE patients were characterized. Patients and Methods The smears of bone marrow aspirates obtained from 17 SLE patients who had bone marrow aspiration due to cytopenia (WBC |
| doi_str_mv | 10.2169/internalmedicine.47.0607 |
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However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias is unknown. Therefore, in the present study, the dysplasias noted in bone marrow aspirates obtained from SLE patients were characterized. Patients and Methods The smears of bone marrow aspirates obtained from 17 SLE patients who had bone marrow aspiration due to cytopenia (WBC<1,500/μl, or Hb<10.5 g/dl, or platelet count <10×104/μl) were examined retrospectively. Of the 17 patients, 4 had a repeat bone marrow aspiration during follow-up. Clinical and laboratory data were obtained from the medical records. Results Of the 17 SLE patients, 12 had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) (5 patients), megaloblastoid changes (4), pseudo-Pelger abnormalities (6), annular nuclear myeloid cells (2), separated nuclear megakaryocytes (4), and micromegakaryocytes (5). In the 4 patients who had follow-up bone marrow aspiration, these dysplasias were correlated with disease activity; some abnormalities disappeared with remission of SLE. Diffuse proliferative glomerulonephritis (3 patients) and cerebral lupus/neuropsychiatric lupus (4 patients) were seen only in patients with dysplasia. Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, and that the dysplasia is reversible during the course of the disease. The presence of dysplasias appears to be associated with disease severity.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.47.0607</identifier><identifier>PMID: 18421190</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adolescent ; Adult ; Biopsy, Fine-Needle ; Bone Diseases, Developmental - etiology ; Bone Diseases, Developmental - pathology ; bone marrow ; Bone Marrow - pathology ; Child ; cytopenia ; dysplasia ; Female ; Humans ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - pathology ; Male ; Megakaryocytes - pathology ; Megaloblasts - pathology ; Middle Aged ; myelodysplastic syndrome ; Myeloid Cells - pathology ; Remission, Spontaneous ; Retrospective Studies ; Severity of Illness Index ; systemic lupus erythematosus</subject><ispartof>Internal Medicine, 2008, Vol.47(8), pp.737-742</ispartof><rights>2008 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-3e0a03c4828155a07e7fd6ed8bb04bd803f5865cbffd18922ebc2dc290cc419e3</citedby><cites>FETCH-LOGICAL-c472t-3e0a03c4828155a07e7fd6ed8bb04bd803f5865cbffd18922ebc2dc290cc419e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18421190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oka, Yumiko</creatorcontrib><creatorcontrib>Kameoka, Junichi</creatorcontrib><creatorcontrib>Hirabayashi, Yasuhiko</creatorcontrib><creatorcontrib>Takahashi, Reiko</creatorcontrib><creatorcontrib>Ishii, Tomonori</creatorcontrib><creatorcontrib>Sasaki, Takeshi</creatorcontrib><creatorcontrib>Harigae, Hideo</creatorcontrib><title>Reversible Bone Marrow Dysplasia in Patients with Systemic Lupus Erythematosus</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective Several reports of bone marrow dysplasia in patients with systemic lupus erythematosus (SLE) have been published. However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias is unknown. Therefore, in the present study, the dysplasias noted in bone marrow aspirates obtained from SLE patients were characterized. Patients and Methods The smears of bone marrow aspirates obtained from 17 SLE patients who had bone marrow aspiration due to cytopenia (WBC<1,500/μl, or Hb<10.5 g/dl, or platelet count <10×104/μl) were examined retrospectively. Of the 17 patients, 4 had a repeat bone marrow aspiration during follow-up. Clinical and laboratory data were obtained from the medical records. Results Of the 17 SLE patients, 12 had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) (5 patients), megaloblastoid changes (4), pseudo-Pelger abnormalities (6), annular nuclear myeloid cells (2), separated nuclear megakaryocytes (4), and micromegakaryocytes (5). In the 4 patients who had follow-up bone marrow aspiration, these dysplasias were correlated with disease activity; some abnormalities disappeared with remission of SLE. Diffuse proliferative glomerulonephritis (3 patients) and cerebral lupus/neuropsychiatric lupus (4 patients) were seen only in patients with dysplasia. Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, and that the dysplasia is reversible during the course of the disease. The presence of dysplasias appears to be associated with disease severity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy, Fine-Needle</subject><subject>Bone Diseases, Developmental - etiology</subject><subject>Bone Diseases, Developmental - pathology</subject><subject>bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Child</subject><subject>cytopenia</subject><subject>dysplasia</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Male</subject><subject>Megakaryocytes - pathology</subject><subject>Megaloblasts - pathology</subject><subject>Middle Aged</subject><subject>myelodysplastic syndrome</subject><subject>Myeloid Cells - pathology</subject><subject>Remission, Spontaneous</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>systemic lupus erythematosus</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtu2zAQRYmiQeOk_YWCq-zk8CWRXLZpXoDzQNquCYoa1Qz0cDlUAv99FdhIgCKbmcWcewc4hFDOloJX9jQOGdLgux6aGOIAS6WXrGL6A1lwqWyhhSw_kgWz3BRiHofkCPGRMWm0FZ_IITdKcG7Zgtw-wBMkjHUH9Ps4AL3xKY3P9McWN53H6Gkc6L3PEYaM9DnmNf25xQx9DHQ1bSak52mb19D7POKEn8lB6zuEL_t9TH5fnP86uypWd5fXZ99WRVBa5EIC80wGZYThZemZBt02FTSmrpmqG8NkW5qqDHXbNtxYIaAOognCshAUtyCPycmud5PGvxNgdn3EAF3nBxgndJXlXEqmZtDswJBGxASt26TY-7R1nLkXl-5_l05p9-Jyjn7d_5jq-fgW3MubgdUOeMTs_8Ar4FOOoYN3m81uaKlfsbD2ycEg_wG-qZOA</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Oka, Yumiko</creator><creator>Kameoka, Junichi</creator><creator>Hirabayashi, Yasuhiko</creator><creator>Takahashi, Reiko</creator><creator>Ishii, Tomonori</creator><creator>Sasaki, Takeshi</creator><creator>Harigae, Hideo</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Reversible Bone Marrow Dysplasia in Patients with Systemic Lupus Erythematosus</title><author>Oka, Yumiko ; Kameoka, Junichi ; Hirabayashi, Yasuhiko ; Takahashi, Reiko ; Ishii, Tomonori ; Sasaki, Takeshi ; Harigae, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-3e0a03c4828155a07e7fd6ed8bb04bd803f5865cbffd18922ebc2dc290cc419e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy, Fine-Needle</topic><topic>Bone Diseases, Developmental - etiology</topic><topic>Bone Diseases, Developmental - pathology</topic><topic>bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Child</topic><topic>cytopenia</topic><topic>dysplasia</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Male</topic><topic>Megakaryocytes - pathology</topic><topic>Megaloblasts - pathology</topic><topic>Middle Aged</topic><topic>myelodysplastic syndrome</topic><topic>Myeloid Cells - pathology</topic><topic>Remission, Spontaneous</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oka, Yumiko</creatorcontrib><creatorcontrib>Kameoka, Junichi</creatorcontrib><creatorcontrib>Hirabayashi, Yasuhiko</creatorcontrib><creatorcontrib>Takahashi, Reiko</creatorcontrib><creatorcontrib>Ishii, Tomonori</creatorcontrib><creatorcontrib>Sasaki, Takeshi</creatorcontrib><creatorcontrib>Harigae, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oka, Yumiko</au><au>Kameoka, Junichi</au><au>Hirabayashi, Yasuhiko</au><au>Takahashi, Reiko</au><au>Ishii, Tomonori</au><au>Sasaki, Takeshi</au><au>Harigae, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversible Bone Marrow Dysplasia in Patients with Systemic Lupus Erythematosus</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>47</volume><issue>8</issue><spage>737</spage><epage>742</epage><pages>737-742</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective Several reports of bone marrow dysplasia in patients with systemic lupus erythematosus (SLE) have been published. However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias is unknown. Therefore, in the present study, the dysplasias noted in bone marrow aspirates obtained from SLE patients were characterized. Patients and Methods The smears of bone marrow aspirates obtained from 17 SLE patients who had bone marrow aspiration due to cytopenia (WBC<1,500/μl, or Hb<10.5 g/dl, or platelet count <10×104/μl) were examined retrospectively. Of the 17 patients, 4 had a repeat bone marrow aspiration during follow-up. Clinical and laboratory data were obtained from the medical records. Results Of the 17 SLE patients, 12 had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) (5 patients), megaloblastoid changes (4), pseudo-Pelger abnormalities (6), annular nuclear myeloid cells (2), separated nuclear megakaryocytes (4), and micromegakaryocytes (5). In the 4 patients who had follow-up bone marrow aspiration, these dysplasias were correlated with disease activity; some abnormalities disappeared with remission of SLE. Diffuse proliferative glomerulonephritis (3 patients) and cerebral lupus/neuropsychiatric lupus (4 patients) were seen only in patients with dysplasia. Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, and that the dysplasia is reversible during the course of the disease. The presence of dysplasias appears to be associated with disease severity.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>18421190</pmid><doi>10.2169/internalmedicine.47.0607</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biopsy, Fine-Needle Bone Diseases, Developmental - etiology Bone Diseases, Developmental - pathology bone marrow Bone Marrow - pathology Child cytopenia dysplasia Female Humans Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - pathology Male Megakaryocytes - pathology Megaloblasts - pathology Middle Aged myelodysplastic syndrome Myeloid Cells - pathology Remission, Spontaneous Retrospective Studies Severity of Illness Index systemic lupus erythematosus |
| title | Reversible Bone Marrow Dysplasia in Patients with Systemic Lupus Erythematosus |
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