The synthesis and biological activity of a novel series of diazepine MMP inhibitors

A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo. A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1. MMP-9 and MMP-13 were prepared and evaluated both in vitro and in vivo.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (19), p.2657-2662
Hauptverfasser:	Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sung, Amy, Walter, Thomas, Sharr, Michele A., Roth, Catherine E., Skotnicki, Jerauld S., Albright, J.Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Azepines - metabolism Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Hydroxamic Acids - chemical synthesis Hydroxamic Acids - pharmacology Matrix Metalloproteinase 1 Matrix Metalloproteinase 9 Matrix Metalloproteinase Inhibitors Medical sciences Mice Organic Chemicals Pharmacology. Drug treatments Protease Inhibitors - pharmacology Pyrazines Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology
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Beschreibung
Zusammenfassung:	A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo. A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1. MMP-9 and MMP-13 were prepared and evaluated both in vitro and in vivo.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00473-9