Fetal Loss after Amniocentesis in a Series of 5,780 Procedures

Objectives: Counseling on prenatal diagnosis requires accurate knowledge of the associated risks, including fetal loss. The objective of our study was to assess this risk of amniocentesis in a single center with several operators. Methods: This retrospective analysis concerns only women with singleton pregnancies who underwent amniocentesis between 14 +0 and 23 +6 weeks’ gestation. Results: During this 4.5-year period, 5,780 amniocenteses were performed, of which we analyzed 5,319. The rate of fetal loss was 70 in 4,858 tests (1.4%), with a lost-to-follow-up rate of 3.8%. Conclusion: Our results for fetal loss are comparable to those in the largest series with fewer operators already published.