A labeled guanidine ligand for studying sweet taste

A labeled guanidine ligand for studying sweet taste

A synthesis of a biotinylated-, coumarin-substituted- N, N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for af...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 1998-04, Vol.8 (7), p.881-884
Hauptverfasser: Feng, Yangbo, Burgess, Kevin, Pledger, David, Cairns, Nick, Linthicum, D.Scott
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biotin - analogs & derivatives
Biotin - chemical synthesis
Biotin - chemistry
Biotin - pharmacokinetics
Biotinylation
Chemoreceptor Cells - physiology
Drug Design
Fluorescent Dyes
Food additives
Food industries
Fundamental and applied biological sciences. Psychology
General aspects
Guanidines - chemical synthesis
Guanidines - chemistry
Guanidines - pharmacokinetics
Humans
Indicators and Reagents
Ligands
Molecular Structure
Spectrometry, Fluorescence
Sweetening Agents - chemical synthesis
Sweetening Agents - chemistry
Sweetening Agents - pharmacokinetics
Taste
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Zusammenfassung:A synthesis of a biotinylated-, coumarin-substituted- N, N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for affinity purification. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00130-9