Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles

A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation sequences can be carried out in a one-pot process. A convenient solution phase me...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-05, Vol.8 (9), p.1089-1092
Hauptverfasser:	Xu, Wei, Mohan, Raju, Morrissey, Michael M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Chemistry Chemistry, Organic - methods Exact sciences and technology Heterocyclic compounds Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Heterocyclic Compounds, 1-Ring Hydrogen-Ion Concentration Indicators and Reagents Models, Molecular Molecular Structure Organic chemistry Organophosphorus Compounds Polymers Preparations and properties
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Beschreibung
Zusammenfassung:	A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation sequences can be carried out in a one-pot process. A convenient solution phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation reactions can be carried out in a one-pot process.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00173-5