cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene

A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22....

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Veröffentlicht in:	DNA research 1998, Vol.5 (5), p.309-313
Hauptverfasser:	Rigolet, M, Rich, T, Gross-Morand, M S, Molina-Gomes, D, Viegas-Pequignot, E, Junien, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Blotting, Northern Brain - metabolism Chromosome Mapping Chromosomes, Human, Pair 6 Cloning, Molecular DNA, Complementary - genetics DNA, Complementary - isolation & purification DNA-Binding Proteins Fetus - metabolism Gene Expression Regulation, Developmental Humans In Situ Hybridization, Fluorescence Inhibitor of Differentiation Proteins Mice Molecular Sequence Data Nervous System Neoplasms - genetics Proteins - chemistry Proteins - genetics Proteins - metabolism Sequence Analysis, DNA Thyroid Gland - metabolism Transcription Factors Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22.3-p23. Northern blot analysis showed that ID4 is mainly expressed in thyroid, brain and fetal tissue and in some nervous system tumor cell lines.
ISSN:	1340-2838
DOI:	10.1093/dnares/5.5.309