Salivary Amylase Activity of Rats Fed a Low Calcium Diet

Wistar strain rats fed low calcium diets (1, 2, 3, 4, 6 and 8 weeks) exhibited changes in secretory function of whole saliva. In particular, there were changes in salivary flow rate, total salivary protein, amylase enzyme activity, salivary amylase content and the level of cyclic AMP in the parotid...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1998, Vol.78(3), pp.279-283
Hauptverfasser:	Wang, Pao-Li, Shirasu, Shinya, Shinohara, Mitsuko, Murakawa, Noboru, Endo, Masaki, Sakata, Shigeki, Okamura, Makoto, Daito, Michiharu, Ohura, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylase Amylases - drug effects Amylases - metabolism Animals Body Weight - drug effects Calcium, Dietary - administration & dosage Cyclic AMP Cyclic AMP - metabolism Low Ca diet Male Organ Size - drug effects Parotid gland Parotid Gland - drug effects Parotid Gland - growth & development Parotid Gland - metabolism Rats Rats, Wistar Saliva Saliva - drug effects Saliva - enzymology Saliva - metabolism Salivary Proteins and Peptides - drug effects Salivary Proteins and Peptides - metabolism Secretory Rate - drug effects Time Factors
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Zusammenfassung:	Wistar strain rats fed low calcium diets (1, 2, 3, 4, 6 and 8 weeks) exhibited changes in secretory function of whole saliva. In particular, there were changes in salivary flow rate, total salivary protein, amylase enzyme activity, salivary amylase content and the level of cyclic AMP in the parotid gland acinar cell. Although there were no changes for the first 3 weeks, the levels increased at week 4 and decreased at week 6. The wet weight of the parotid gland started to decrease at week 4. These results suggest that when fed low calcium diets for long periods of time, rats develop defective salivary secretion.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.78.279