Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India
The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls....
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| Veröffentlicht in: | Neurochemical research 2008-06, Vol.33 (6), p.1145-1149 |
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| creator | Babu, G. Nagesh Kumar, Alok Chandra, Ramesh Puri, S. K. Kalita, Jayantee Misra, U. K. |
| description | The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls. Serum TNF-α levels and IFN-γ levels were significantly (
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| doi_str_mv | 10.1007/s11064-007-9564-x |
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P
< 0.001) elevated in ALS patients. We also observed NO levels to be significantly (
P
< 0.05) increased with respect to normal subjects. We further noticed positive correlation between the duration of ALS and these proinflammatory molecule levels. Exitotoxicity and oxidative stress are known to play a crucial role in the neurodegeneration observed in ALS. Since high levels of TNF-α are known to be cytotoxic, it could be that a complex interplay of these effectors may be one of the factors underlying the progression of ALS. This study confirms the involvement of inflammation in ALS and the need to develop surrogate markers to check the progression of this disease.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-007-9564-x</identifier><identifier>PMID: 18246426</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - immunology ; Amyotrophic Lateral Sclerosis - physiopathology ; Biochemistry ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Disease Progression ; Female ; Humans ; India ; Inflammation - blood ; Interferon-gamma - blood ; Male ; Middle Aged ; Neurochemistry ; Neurology ; Neurosciences ; Nitric Oxide - blood ; Original Paper ; Prospective Studies ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Neurochemical research, 2008-06, Vol.33 (6), p.1145-1149</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-394c494ee6d2e02dec2b602b795a3c3da9a22494d375726eb5a80131f3b928623</citedby><cites>FETCH-LOGICAL-c431t-394c494ee6d2e02dec2b602b795a3c3da9a22494d375726eb5a80131f3b928623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-007-9564-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-007-9564-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18246426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babu, G. Nagesh</creatorcontrib><creatorcontrib>Kumar, Alok</creatorcontrib><creatorcontrib>Chandra, Ramesh</creatorcontrib><creatorcontrib>Puri, S. K.</creatorcontrib><creatorcontrib>Kalita, Jayantee</creatorcontrib><creatorcontrib>Misra, U. K.</creatorcontrib><title>Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls. Serum TNF-α levels and IFN-γ levels were significantly (
P
< 0.001) elevated in ALS patients. We also observed NO levels to be significantly (
P
< 0.05) increased with respect to normal subjects. We further noticed positive correlation between the duration of ALS and these proinflammatory molecule levels. Exitotoxicity and oxidative stress are known to play a crucial role in the neurodegeneration observed in ALS. Since high levels of TNF-α are known to be cytotoxic, it could be that a complex interplay of these effectors may be one of the factors underlying the progression of ALS. This study confirms the involvement of inflammation in ALS and the need to develop surrogate markers to check the progression of this disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - blood</subject><subject>Amyotrophic Lateral Sclerosis - immunology</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Biochemistry</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>India</subject><subject>Inflammation - blood</subject><subject>Interferon-gamma - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nitric Oxide - blood</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtLxDAUhYMozvj4AW4kuHBXzaNNmqWILxgfoK5D2t46HdtmTFJx_r0ZZmBAEF3lkPudE3IPQkeUnFFC5LmnlIg0iTJRWRRfW2hMM8kToQjfRmPC4yWniozQnvczQqKL0V00ojlLRcrEGNVXLXyaABW-6-vWdJ0J1i3wvXHv4DxuemzwjbPDHNsaX3QLG5ydT5sST6LJmRY_ly046xuPn0xooA8e1852-MG6MAXXx9yqMQdopzath8P1uY9er69eLm-TyePN3eXFJClTTkPCVVqmKgUQFQPCKihZIQgrpMoML3lllGEsAhWXmWQCiszkhHJa80KxXDC-j05XuXNnPwbwQXeNL6FtTQ928FooSrJc0j9BRmSe5kL8AxRC5VJF8OQHOLOD6-NvNWNU5pkgPEJ0BZVxZ95Breeu6YxbaEr0slO96lQv5bJT_RU9x-vgoeig2jjWJUaArQAfR_0buM3Lv6d-A2BWq9c</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Babu, G. 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Nagesh ; Kumar, Alok ; Chandra, Ramesh ; Puri, S. K. ; Kalita, Jayantee ; Misra, U. 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Nagesh</au><au>Kumar, Alok</au><au>Chandra, Ramesh</au><au>Puri, S. K.</au><au>Kalita, Jayantee</au><au>Misra, U. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>33</volume><issue>6</issue><spage>1145</spage><epage>1149</epage><pages>1145-1149</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls. Serum TNF-α levels and IFN-γ levels were significantly (
P
< 0.001) elevated in ALS patients. We also observed NO levels to be significantly (
P
< 0.05) increased with respect to normal subjects. We further noticed positive correlation between the duration of ALS and these proinflammatory molecule levels. Exitotoxicity and oxidative stress are known to play a crucial role in the neurodegeneration observed in ALS. Since high levels of TNF-α are known to be cytotoxic, it could be that a complex interplay of these effectors may be one of the factors underlying the progression of ALS. This study confirms the involvement of inflammation in ALS and the need to develop surrogate markers to check the progression of this disease.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18246426</pmid><doi>10.1007/s11064-007-9564-x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - immunology Amyotrophic Lateral Sclerosis - physiopathology Biochemistry Biomarkers - blood Biomedical and Life Sciences Biomedicine Cell Biology Disease Progression Female Humans India Inflammation - blood Interferon-gamma - blood Male Middle Aged Neurochemistry Neurology Neurosciences Nitric Oxide - blood Original Paper Prospective Studies Tumor Necrosis Factor-alpha - blood |
| title | Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India |
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