Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India

Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India

The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls....

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Veröffentlicht in:Neurochemical research 2008-06, Vol.33 (6), p.1145-1149
Hauptverfasser: Babu, G. Nagesh, Kumar, Alok, Chandra, Ramesh, Puri, S. K., Kalita, Jayantee, Misra, U. K.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Amyotrophic Lateral Sclerosis - blood
Amyotrophic Lateral Sclerosis - immunology
Amyotrophic Lateral Sclerosis - physiopathology
Biochemistry
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cell Biology
Disease Progression
Female
Humans
India
Inflammation - blood
Interferon-gamma - blood
Male
Middle Aged
Neurochemistry
Neurology
Neurosciences
Nitric Oxide - blood
Original Paper
Prospective Studies
Tumor Necrosis Factor-alpha - blood
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Zusammenfassung:The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls. Serum TNF-α levels and IFN-γ levels were significantly ( P  
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-007-9564-x