Synthesis of 4′-modified noraristeromycins to clarify the effect of the 4′-hydroxyl groups for inhibitory activity against S-adenosyl- l-homocysteine hydrolase

4′-Modified noraristeromycin (NAM) analogs, 4′-sulfo-, 4′-sulfamoy, 4′-azido and 4′-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl- l-homocysteine hydrolase were investigated.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-04, Vol.18 (8), p.2615-2618
Hauptverfasser:	Ando, Takayuki, Kojima, Kenji, Chahota, Praveen, Kozaki, Atsushi, Milind, Nikalje D., Kitade, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemical synthesis Adenosine - chemistry Adenosine - pharmacology Adenosylhomocysteinase - antagonists & inhibitors Adenosylhomocysteinase - metabolism Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Aristeromycin Biological and medical sciences Carbocyclic adenine nucleoside Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Hydroxylation Medical sciences Molecular Structure Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - enzymology S-adenosyl- l-homocysteine hydrolase Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	4′-Modified noraristeromycin (NAM) analogs, 4′-sulfo-, 4′-sulfamoy, 4′-azido and 4′-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl- l-homocysteine hydrolase were investigated.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.03.029