Antibodies to the E2 protein of GB Virus C/hepatitis G virus: low prevalence in Asian countries

Epidemiological investigations of GB virus C (GBV C)/hepatitis G virus (HGV), an infectious agent discovered in 1995/1996, are facilitated by a recently developed immunoassay for the detection of antibodies to the viral envelope 2 protein (anti-E2).We used this assay to establish GBVC/HGV prevalence in seven European, African, and Asian countries.A total of 1579 serum samples from healthy adults lacking prior exposure to known parenteral risk factors was screened.Anti-E2 positivity ranged from 13.6 % (Italy) to 7.7 % (Mauritius) in the European and African countries investigated.Anti-E2 prevalence was exceedingly low in the Philippines and Sri Lanka.This observation might be attributable to socio-economical and demographic factors.