Product activation of human erythrocyte AMP deaminase

IMP was found to activate AMP deaminase in crude glucose-depleted human erythrocyte lysates. Activation of the enzyme by IMP is due to prevention of the inhibitory effect of inorganic phosphate. At 1 mM AMP and 2–3 mM phosphate the addition of 2–5 mM IMP accelerates the AMP deamination two to three...

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Veröffentlicht in:	FEBS letters 1998-11, Vol.440 (1), p.64-66
Hauptverfasser:	Mosharov, E.V, Vitvitsky, V.M, Ataullakhanov, F.I
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diphosphoglycerate - pharmacology Adenosine Monophosphate - metabolism Adenosine Monophosphate - pharmacology Adenylate metabolism AMP deaminase AMP Deaminase - antagonists & inhibitors AMP Deaminase - blood Cell Extracts Dialysis Dose-Response Relationship, Drug Enzyme Activation Erythrocyte Erythrocytes - drug effects Erythrocytes - enzymology Humans Hypoxanthine - pharmacology Inosine - pharmacology Inosine Monophosphate - pharmacology Kinetics Phosphates - pharmacology Potassium Compounds - pharmacology
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Beschreibung
Zusammenfassung:	IMP was found to activate AMP deaminase in crude glucose-depleted human erythrocyte lysates. Activation of the enzyme by IMP is due to prevention of the inhibitory effect of inorganic phosphate. At 1 mM AMP and 2–3 mM phosphate the addition of 2–5 mM IMP accelerates the AMP deamination two to three times.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(98)01429-X