Reduced tyrosine kinase receptor C mRNA levels in the frontal cortex of patients with schizophrenia

Using a quantitative RNA-PCR approach tyrosine kinase receptor (trk) C mRNA levels were determined in brain material from the frontal cortex (BA10), temporal cortex (BA20) and cerebellum of control specimen and patients with schizophrenia, bipolar disorder or non-psychotic depression (15 subjects ea...

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Veröffentlicht in:	Neuroscience letters 1998-11, Vol.257 (2), p.65-68
Hauptverfasser:	Schramm, Maja, Falkai, Peter, Feldmann, Nicole, Knable, Michael B, Bayer, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aged Antipsychotic Agents - administration & dosage Antipsychotic Agents - therapeutic use Biological and medical sciences Bipolar disorder Bipolar Disorder - metabolism Cerebellum - metabolism Competitive RT-PCR Depressive Disorder - metabolism Female Fluphenazine - administration & dosage Fluphenazine - therapeutic use Frontal Lobe - metabolism Humans Male Medical sciences Middle Aged Post-mortem Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptor Protein-Tyrosine Kinases - genetics Receptor, trkC Receptors, Nerve Growth Factor - genetics Reference Values RNA RNA, Messenger - metabolism Schizophrenia Schizophrenia - metabolism Temporal Lobe - metabolism trk C Unipolar depression
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Zusammenfassung:	Using a quantitative RNA-PCR approach tyrosine kinase receptor (trk) C mRNA levels were determined in brain material from the frontal cortex (BA10), temporal cortex (BA20) and cerebellum of control specimen and patients with schizophrenia, bipolar disorder or non-psychotic depression (15 subjects each). In the frontal cortex of schizophrenics there was a 5.8-fold reduction of trk C mRNA levels, which reached statistical significance ( P
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(98)00807-6