Pancreatic Cancer Associated With Granulocyte-Colony Stimulating Factor Production Confirmed by Immunohistochemistry

We report an 83-year-old man with pancreatic body cancer of 4.5 cm in diameter. Peripheral leukocyte count was 15,700/μl and the serum concentration of granulocyte-colony stimulating factor (G-CSF) was 123 pg/ml (normal, 6.0-21.9 pg/ml) on admission. Furthermore, not only K-ras codon 12 (GGT → GAT)...

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Veröffentlicht in:Journal of clinical gastroenterology 1998-12, Vol.27 (4), p.357-360
Hauptverfasser: Ohtsubo, Koushiro, Mouri, Hisatsugu, Sakai, Junta, Akasofu, Miwa, Yamaguchi, Yasushi, Watanabe, Hiroyuki, Gabata, Toshifumi, Motoo, Yoshiharu, Okai, Takashi, Sawabu, Norio
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Sprache:eng
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Zusammenfassung:We report an 83-year-old man with pancreatic body cancer of 4.5 cm in diameter. Peripheral leukocyte count was 15,700/μl and the serum concentration of granulocyte-colony stimulating factor (G-CSF) was 123 pg/ml (normal, 6.0-21.9 pg/ml) on admission. Furthermore, not only K-ras codon 12 (GGT → GAT) but also p53 at codon 247 (CGG → CCG) mutations were identified in the pancreatic juice aspirated endoscopically. We performed chemotherapy with two courses of 5-fluorouracil, pirarubicin hydrochloride, and mitomycin-C, resulting in no beneficial effect. After the second course the patient developed interstitial pneumonia, probably caused by anti-cancer drugs, and died 4 months after the tumor was detected. In the autopsy tissue, the tumor macroscopically occupied the pancreas body and was 7 × 6 × 5 cm in size. Histopathologic diagnosis of the tumor was poorly differentiated adenosquamous carcinoma. Immunohistochemical staining of the autopsy tissue showed that pancreatic cancer cells were positive for G-CSF. This is the first case report of G-CSF-positive pancreatic cancer confirmed by immunohistochemistry.
ISSN:0192-0790
1539-2031
DOI:10.1097/00004836-199812000-00018