An Adrenaline (and Gold?) Rush for the GPCR Community

An Adrenaline (and Gold?) Rush for the GPCR Community

G-Protein-coupled receptors are one of the largest protein families found in metazoans. Using several novel strategies, the first atomic resolution structures of a receptor that is activated by a diffusible ligand have been determined.

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Bibliographische Detailangaben
Veröffentlicht in:ACS chemical biology 2007-12, Vol.2 (12), p.783-786
Hauptverfasser: Blumer, Kendall J, Thorner, Jeremy
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography, X-Ray
Epinephrine - chemistry
Epinephrine - metabolism
Models, Molecular
Protein Structure, Tertiary
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - metabolism
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Beschreibung
Zusammenfassung:G-Protein-coupled receptors are one of the largest protein families found in metazoans. Using several novel strategies, the first atomic resolution structures of a receptor that is activated by a diffusible ligand have been determined.
ISSN:1554-8929
1554-8937
DOI:10.1021/cb7002412