Fungal neuroinfections: rare disease but unacceptably high mortality

Within last 25 years we have observed 20 cases of fungal meningitis and/or cerebral abscesses. Commonest etiologic agens was Candida spp. (C. albicans 9 of 20). Molds were responsible for 4 cases of brain abscess. Mortality was 50% what seems to be very high. Extremely high mortality is caused by de...

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Veröffentlicht in:	Neuro-endocrinology letters 2007-06, Vol.28 Suppl 2, p.25-26
Hauptverfasser:	Njambi, S, Huttova, M, Kovac, M, Freybergh, P F, Bauer, F, Muli, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - microbiology Antifungal Agents - therapeutic use Brain Abscess - complications Brain Abscess - drug therapy Brain Abscess - microbiology Brain Abscess - mortality Candidiasis - drug therapy Candidiasis - mortality Child Child, Preschool Humans Infant Infant, Newborn Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - drug therapy Meningitis, Cryptococcal - mortality Meningitis, Fungal - complications Meningitis, Fungal - drug therapy Meningitis, Fungal - microbiology Meningitis, Fungal - mortality Rare Diseases Retrospective Studies
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Zusammenfassung:	Within last 25 years we have observed 20 cases of fungal meningitis and/or cerebral abscesses. Commonest etiologic agens was Candida spp. (C. albicans 9 of 20). Molds were responsible for 4 cases of brain abscess. Mortality was 50% what seems to be very high. Extremely high mortality is caused by delayed onset of therapy, severe underlying disease and multiresistant fungal organisms such as Mucorales, Fusarium solani and Aureobasidium.
ISSN:	0172-780X