Genetic variability in E6 and E7 genes of human papillomavirus -16, -18, -31 and -33 from HIV-1-positive women in Italy

Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity...

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Veröffentlicht in:	The New microbiologica 2007-10, Vol.30 (4), p.377-382
Hauptverfasser:	Garbuglia, Anna Rosa, Carletti, Fabrizio, Minosse, Claudia, Piselli, Pierluca, Zaniratti, M Stefania, Serraino, Diego, Capobianchi, M Rosaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cervix Uteri - virology Female Genes, Viral Genetic Variation HIV Infections - complications HIV-1 Human immunodeficiency virus Human papillomavirus Humans Italy Oncogene Proteins, Viral - genetics Papillomaviridae - classification Papillomaviridae - genetics Papillomavirus E7 Proteins - genetics Papillomavirus Infections - complications Papillomavirus Infections - virology
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Zusammenfassung:	Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity were 1.2-3-3%, and 0.8-1.8 for E6 and 0.6-2.7%, and 0.6-2.0% for E7, respectively. HPV-31, the second most common HPV type, showed the highest diversity for both regions. On the whole, 26 out of 59 mutations were non-synonymous. The variability of these proteins may have implications in HPV vaccine strategies.
ISSN:	1121-7138