Calcium Signaling

Calcium Signaling

Calcium ions (Ca 2+) impact nearly every aspect of cellular life. This review examines the principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the mechanisms that control Ca 2+ levels in the cytoplasm and organelles. Also discussed is the highly localized nature o...

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Veröffentlicht in:Cell 2007-12, Vol.131 (6), p.1047-1058
1. Verfasser: Clapham, David E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium Signaling
Calcium-Binding Proteins - metabolism
Calcium-Transporting ATPases - metabolism
Calmodulin - metabolism
Cell Membrane - metabolism
Cell Movement
Humans
Models, Molecular
Signal Transduction
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Beschreibung
Zusammenfassung:Calcium ions (Ca 2+) impact nearly every aspect of cellular life. This review examines the principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the mechanisms that control Ca 2+ levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca 2+-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2007.11.028