The Mx GTPase family of interferon-induced antiviral proteins

Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.

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Bibliographische Detailangaben
Veröffentlicht in:	Microbes and infection 2007-11, Vol.9 (14), p.1636-1643
Hauptverfasser:	Haller, Otto, Stertz, Silke, Kochs, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - classification Antiviral Agents - metabolism Antiviral Agents - pharmacology Bunyaviruses Cattle Dogs Dynamin Endoplasmic reticulum GTP Phosphohydrolases - classification GTP Phosphohydrolases - metabolism GTP Phosphohydrolases - pharmacology GTP-Binding Proteins - classification GTP-Binding Proteins - metabolism GTP-Binding Proteins - pharmacology Humans Influenza virus Interferon Interferons - pharmacology Mice MxGTPase Myxovirus Resistance Proteins PML nuclear bodies Rats SUMO-1 Virus Replication - drug effects Viruses - drug effects
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Beschreibung
Zusammenfassung:	Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2007.09.010