The Decarboxylative Blaise Reaction
Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lachrymatory reagent,...
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| Veröffentlicht in: | Journal of organic chemistry 2007-12, Vol.72 (26), p.10261-10263 |
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| container_end_page | 10263 |
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| container_issue | 26 |
| container_start_page | 10261 |
| container_title | Journal of organic chemistry |
| container_volume | 72 |
| creator | Lee, Jae Hoon Choi, Bo Seung Chang, Jay Hyok Lee, Hee Bong Yoon, Joo-Yong Lee, Jaeick Shin, Hyunik |
| description | Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lachrymatory reagent, and is possible with 0.5−1.0 equiv of zinc chloride. |
| doi_str_mv | 10.1021/jo701743m |
| format | Article |
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Org. Chem</addtitle><description>Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. 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Org. Chem</addtitle><date>2007-12-21</date><risdate>2007</risdate><volume>72</volume><issue>26</issue><spage>10261</spage><epage>10263</epage><pages>10261-10263</pages><issn>0022-3263</issn><eissn>1520-6904</eissn><coden>JOCEAH</coden><abstract>Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lachrymatory reagent, and is possible with 0.5−1.0 equiv of zinc chloride.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18047371</pmid><doi>10.1021/jo701743m</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of organic chemistry, 2007-12, Vol.72 (26), p.10261-10263 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Acrylates - chemical synthesis Acrylates - chemistry Aliphatic compounds Catalysis Chemistry Chlorides - chemistry Decarboxylation Exact sciences and technology Malonates - chemistry Molecular Structure Nitriles - chemistry Organic chemistry Potassium - chemistry Preparations and properties Solvents - chemistry Zinc Compounds - chemistry |
| title | The Decarboxylative Blaise Reaction |
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