The Decarboxylative Blaise Reaction

Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lachrymatory reagent,...

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Veröffentlicht in:	Journal of organic chemistry 2007-12, Vol.72 (26), p.10261-10263
Hauptverfasser:	Lee, Jae Hoon, Choi, Bo Seung, Chang, Jay Hyok, Lee, Hee Bong, Yoon, Joo-Yong, Lee, Jaeick, Shin, Hyunik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemical synthesis Acrylates - chemistry Aliphatic compounds Catalysis Chemistry Chlorides - chemistry Decarboxylation Exact sciences and technology Malonates - chemistry Molecular Structure Nitriles - chemistry Organic chemistry Potassium - chemistry Preparations and properties Solvents - chemistry Zinc Compounds - chemistry
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Beschreibung
Zusammenfassung:	Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lachrymatory reagent, and is possible with 0.5−1.0 equiv of zinc chloride.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo701743m