Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes

Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes

The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irr...

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Veröffentlicht in:Organic letters 2007-12, Vol.9 (26), p.5337-5339
Hauptverfasser: Rasmussen, Lars Kyhn, Boren, Brant C, Fokin, Valery V
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Azides - chemistry
Catalysis
Cyclization
Ruthenium - chemistry
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Zusammenfassung:The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol701912s