Efficacy of Different Intraocular Lens Materials and Optic Edge Designs in Preventing Posterior Capsular Opacification: A Meta-Analysis

Purpose To evaluate the efficacy of different intraocular lens (IOL) materials and optic edge designs in preventing posterior capsular opacification (PCO). Design Systematic review and meta-analysis. Methods Pertinent studies were selected through an electronic search of the Cochrane Library, MEDLINE, and Embase. The randomized controlled trials meeting the predefined criteria were reviewed systematically by meta-analysis. The treatment effects were measured as risk difference, and the pooled estimates were computed according to a random effect model. Results In total, 23 randomized controlled trials were included in the present meta-analysis. The pooled risk differences of Nd:YAG laser capsulotomy rates were −24% (95% confidence interval [CI], −29% to −20%) comparing acrylic with polymethylmethacrylate (PMMA) lenses; −9% (95% CI, −17% to −1%) comparing silicone with PMMA lenses; 14% (95% CI, −8% to 36%) comparing hydrogel with PMMA lenses; 4% (95% CI, −2% to 10%) comparing silicone with acrylic lenses; 19% (95% CI, 8% to 30%) comparing hydrogel with acrylic lenses; and 28% (95% CI, 10% to 46%) comparing hydrogel with silicone lenses. The pooled risk differences of PCO rates were −39% (95% CI, −47% to −31%) comparing acrylic with PMMA lenses; −14% (95% CI, −29% to 0%) comparing silicone with acrylic lenses; 56% (95% CI, 36% to 75%) comparing hydrogel with acrylic lenses; and 48% (95% CI, 31% to 64%) comparing hydrogel with silicone lenses. When comparing sharp with rounded-edge designs, pooled risk differences of capsulotomy rates were −47% (95% CI, −77% to −17%) in PMMA lenses, −22% (95% CI, −47% to 2%) in acrylic lenses, and −9% (95% CI, −17% to 0%) in silicone lenses; pooled risk differences of PCO rates were −28% (95% CI, −50% to −7%) in acrylic lenses and −37% (95% CI, −46% to −27%) in silicone lenses. Conclusions The rates of PCO and Nd:YAG laser capsulotomy may be influenced by different IOL biomaterials and optic edge designs. The lenses made by acrylic and silicone and those with sharp optic edges are superior in lowering the rates of PCO and laser capsulotomy.