Discorhabdin W, the First Dimeric Discorhabdin

Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-12, Vol.68 (12), p.1796-1798
Hauptverfasser:	Lang, Gerhard, Pinkert, André, Blunt, John W, Munro, Murray H. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences General aspects General pharmacology Leukemia P388 Medical sciences Molecular Structure New Zealand Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Quinones - chemistry Quinones - isolation & purification Quinones - pharmacology Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Thiazepines - chemistry Thiazepines - isolation & purification Thiazepines - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (3), G*/I (4), and L (5) were also isolated from the same sponge.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050333f