On-Demand Generation of an Efficient Catalyst for Pyridine Formation from Unactivated Nitriles and α,ω-Diynes Using CoCl2-6H2O, dppe, and Zn

On-Demand Generation of an Efficient Catalyst for Pyridine Formation from Unactivated Nitriles and α,ω-Diynes Using CoCl2-6H2O, dppe, and Zn

A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and α,ω-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2−6H2O in the presence of Zn powder (10 mol %) could proceed at rt to ∼50 °C with high functio...

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Veröffentlicht in:Organic letters 2007-03, Vol.9 (5), p.931-934
Hauptverfasser: Kase, Kouki, Goswami, Avijit, Ohtaki, Kazuhiko, Tanabe, Emi, Saino, Naoko, Okamoto, Sentaro
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Cobalt - chemistry
Ligands
Molecular Structure
Nitriles - chemistry
Phenyl Ethers - chemistry
Phosphines - chemistry
Pyridines - chemistry
Water - chemistry
Zinc - chemistry
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Zusammenfassung:A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and α,ω-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2−6H2O in the presence of Zn powder (10 mol %) could proceed at rt to ∼50 °C with high functional compatibility and regioselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol070037p