Marine Diterpenoids with a Briarane Skeleton from the Okinawan Soft Coral Pachyclavularia violacea

Five new briarane-type diterpenoids, pachyclavulides E (5), F (6), G (7), H (8) and I (9), were isolated from the Okinawan soft coral Pachyclavularia violacea. The structures of these compounds were elucidated based on the results of spectroscopic analysis. Compound 5 showed a weak growth-inhibitory...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2007/12/01, Vol.55(12), pp.1671-1676
Hauptverfasser:	Ito, Hisanaka, Iwasaki, Junya, Sato, Yuki, Aoyagi, Miwako, Iguchi, Kazuo, Yamori, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthozoa - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology briarane skeleton Diterpenes - chemistry Diterpenes - pharmacology Drug Screening Assays, Antitumor Humans Japan Magnetic Resonance Spectroscopy marine diterpenoid Molecular Conformation Pachyclavularia violacea soft coral Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Zusammenfassung:	Five new briarane-type diterpenoids, pachyclavulides E (5), F (6), G (7), H (8) and I (9), were isolated from the Okinawan soft coral Pachyclavularia violacea. The structures of these compounds were elucidated based on the results of spectroscopic analysis. Compound 5 showed a weak growth-inhibitory activity in vitro toward cancer cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.55.1671