Polymer-Caged Lipsomes:  A pH-Responsive Delivery System with High Stability

Polymer-Caged Lipsomes:  A pH-Responsive Delivery System with High Stability

Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2‘-(ethylenedioxy)bis(ethyl...

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Veröffentlicht in:Journal of the American Chemical Society 2007-12, Vol.129 (49), p.15096-15097
Hauptverfasser: Lee, Sang-Min, Chen, Haimei, Dettmer, Christine M, O'Halloran, Thomas V, Nguyen, SonBinh T
Format: Artikel
Sprache:eng
Schlagworte:
Acrylic Resins - chemistry
Animals
Cattle
Cholesterol - analogs & derivatives
Cholesterol - chemistry
Drug Delivery Systems
Drug Stability
Fluoresceins - chemistry
Fluorescent Dyes - chemistry
Hydrogen-Ion Concentration
Lipid Bilayers - chemistry
Liposomes - blood
Liposomes - chemical synthesis
Liposomes - chemistry
Microscopy, Electron, Transmission
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Zusammenfassung:Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2‘-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja070748i