Expression of Natural Cytotoxicity Receptors and a2V-ATPase on Peripheral Blood NK Cell Subsets in Women with Recurrent Spontaneous Abortions and Implantation Failures

Problem Natural cytotoxicity receptors (NCRs) are unique markers, which regulate NK cell cytotoxicity and cytokine production. a2V‐ATPase is expressed on subsets of PBMC and regulates the extracellular environment, which facilitates NK cytotoxicity or cytokine secretion. In this study, we aim to investigate the expression of NCRs and a2V‐ATPase in peripheral blood NK cells of women with recurrent spontaneous abortions (RSA) or implantation failures. Method of study Peripheral blood NK cells (CD56dim and CD56bright were analyzed for the expression of NCRs (NKp46, NKp44 and NKp30) and a2V‐ATPase using 3‐color flow cytometry in women with RSA (n=24), implantation failures (n=19) or normal healthy women (n=13). Results CD56+/NKp46+ cells were markedly decreased (P