Comparison of Full Genome Sequences Between Two Hepatitis B Virus Strains With or Without preC Mutation (A1896) from a Single Korean Hepatocellular Carcinoma Patient

This report describes the full-length sequences of 2 HBV clones from a hepatocellular carcinoma (HCC) patient, one with preC mutation (1896A) and the other without preC mutation. The high level of discrepancy in mutation frequency between these 2 strains was observed in the Core (C) region among 4 O...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2007-04, Vol.17 (4), p.701-704
Hauptverfasser:	Kim, H. (Seoul National University, Seoul, Republic of Korea), Jee, Y.M. (National Institute of Health, Seoul, Republic of Korea), Mun, H.S. (Seoul National University, Seoul, Republic of Korea), Song, B.C. (Cheju National University, Jeju, Republic of Korea), Park, J.H. (Seoul National University, Seoul, Republic of Korea), Hyun, J.W. (Cheju National University, Jeju, Republic of Korea), Hwang, E.S. (Seoul National University, Seoul, Republic of Korea), Cha, C.Y. (Seoul National University, Seoul, Republic of Korea), Kook, Y.H. (Seoul National University, Seoul, Republic of Korea), Kim, B.J. (Seoul National University, Seoul, Republic of Korea), E-mail: kbumjoon@snu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Biotechnology Carcinoma, Hepatocellular - virology full-length genome sequence Fundamental and applied biological sciences. Psychology Genome, Viral Hepatitis B e Antigens - genetics hepatitis B virus (HBV) Hepatitis B virus - classification Hepatitis B virus - genetics hepatocellular carcinoma (HCC) Humans Liver Neoplasms - virology MUTACION MUTATION preC mutation Promoter Regions, Genetic quasispecies
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Zusammenfassung:	This report describes the full-length sequences of 2 HBV clones from a hepatocellular carcinoma (HCC) patient, one with preC mutation (1896A) and the other without preC mutation. The high level of discrepancy in mutation frequency between these 2 strains was observed in the Core (C) region among 4 ORFs. These data support previous results that Korean HBV strains, belonging to genotype C2, are prone to mutations. It is possible that the mutations (BCP and preC mutations) associated with the HBeAg defective production might contribute to the diversity of mutations related to HBV persistence, playing an important role in hepatocarcinogenesis in this patient.
ISSN:	1017-7825